Conditioning of BM for engraftment of lower number of HSCs
In Hematopoietic stem cell field, there is a constant effort to improve and to find better conditioning methods for long term
engraftment of transplanted stem cells. We are interested in developing conditioning methods that allows transplantation studies
with low stem cell number. This system will be essential to study BM failure models where the availability of stem cells is limited.
HSC Mobilization
Hematopoietic stem cells (HSCs) typically reside in the bone marrow and rarely move out of the bone marrow. Inducing HSCs to move out of the bone marrow and into circulation is called mobilization. Mobilization of HSCs is important for the collection of HSCs from peripheral blood for both autologous and allogenic stem cell transplantation following intensive chemo-radiation therapy. We are currently identifying new compounds that are capable of improving mobilization of HSCs.