2023
A Critical Role of RUNX1 in Governing Megakaryocyte-Primed Hematopoietic Stem Cell Differentiation
Wang C, Tu Z, Cai X, Wang W, Davis AK, Nattamai KJ, Paranjpe A, Dexheimer P, Wu J, Huang LF, Geiger H, Huang G, Zheng Y.
Blood Adv. 2023 Jan
2022
Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice
Montserrat-Vazquez S, Ali NJ, Matteini F, Lozano J, Zhaowei T, Mejia-Ramirez E, Marka G, Vollmer A, Soller K, Sacma M, Sakk V, Mularoni L, Mallm JP, Plass M, Zheng Y, Geiger H, Florian MC
NPJ Regen Med. 2022 Dec
Fast and high-fidelity in situ 3D imaging protocol for stem cells and niche components for mouse organs and tissues
Mehmet Saçma, Francesca Matteini, Medhanie A. Mulaw, Ali Hageb, Ruzhica Bogeska, Vadim Sakk, Angelika Vollmer, Gina Marka, Karin Soller, Michael D. Milsom, Maria Carolina Florian and Hartmut Geiger
Star Protocols. 2022 Jun
A Limited Role for AMD3100 Induced Stem Cell Mobilization for Modulation of Thoracic Trauma Outcome
Vogel M, Möhrle B, Sakk V, Brown A, Palmer A, Braumüller S, Huber-Lang M, Allgöwer A, Cancelas JA, Geiger H.
Shock. 2022 Jun
Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift
Hageb A, Thalheim T, Nattamai KJ, Möhrle B, Saçma M, Sakk V, Thielecke L, Cornils K, Grandy C, Port F, Gottschalk KE, Mallm JP, Glauche I, Galle J, Mulaw MA, Geiger H
Life Sci Alliance. 2022 Apr
Aging of intestinal stem cells
Nalapareddy K, Zheng Y, Geiger H
Stem Cell Reports. 2022 Apr
Autophagy in mesenchymal progenitors protects mice against bone marrow failure after severe intermittent stress
Landspersky T, Saçma M, et al., Geiger H, Schreck C, Oostendorp RAJ
Blood. 2022 Feb
Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity
Amoah A, Keller A, Emini R, Hoenicka M, Liebold A, Vollmer A, Eiwen K, Soller K, Sakk V, Zheng Y, Florian MC, Geiger H
Haematologica. 2022 Feb
2021
Septins in Stem Cells
Schuster T, Geiger H
Front Cell Dev Biol. 2021 Dec
Cdc42-Borg4-Septin7 axis regulates HSC polarity and function
Kandi R, Senger K, Grigoryan A, Soller K, Sakk V, Schuster T, Eiwen K, Menon MB, Gaestel M, Zheng Y, Florian MC, Geiger H
EMBO Rep. 2021 Dec
Autophagy In Mesenchymal Progenitors Protects Mice Against Bone Marrow Failure After Severe Intermittent Stress
Landspersky T, Saçma M, Rivière J, et al., Geiger H, Schreck C, Oostendorp RAJ
Blood. 2021 Oct
Reconstructing Boolean network ensembles from single-cell data for unraveling dynamics in the aging of human hematopoietic stem cells
Schwab JD, Ikonomi N, Werle SD, Weidner FM, Geiger H, Kestler HA.
Comput Struct Biotechnol J. 2021 Sep
Persistent JunB activation in fibroblasts disrupts stem cell niche interactions enforcing skin aging
Maity P, Singh K, Krug L, Koroma A, Hainzl A, Bloch W, Kochanek S, Wlaschek M, Schorpp-Kistner M, Angel P, Ignatius A, Geiger H, Scharffetter-Kochanek K.
Cell Rep. 2021 Aug
An aged bone marrow niche restrains rejuvenated hematopoietic stem cells
Guidi N, Marka G, Sakk V, Zheng Y, Florian MC, Geiger H.
Stem Cells. 2021 Apr
Attrition of X Chromosome Inactivation in Aged Hematopoietic Stem Cells
Grigoryan A, Pospiech J, Krämer S, Lipka D, Liehr T, Geiger H, Kimura H, Mulaw MA, Florian MC.
Stem Cell Reports. 2021 Apr
Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells.
Nalapareddy K, Hassan A, Sampson LL, Zheng Y, Geiger H.
iScience. 2021 Mar
A Wnt5a-Cdc42 axis controls aging and rejuvenation of hair-follicle stem cells
Tiwari RL, Mishra P, Martin N, George NO, Sakk V, Soller K, Nalapareddy K, Nattamai K, Scharffetter-Kochanek K, Florian MC, Geiger H.
Aging (Albany NY). 2021 Feb
Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity
Amoah A, Keller A, Emini R, Hoenicka M, Liebold A, Vollmer A, Eiwen K, Soller K, Sakk V, Zheng Y, Florian MC, Geiger H.
Haematologica. 2021 Jan
2020
Repolarization of HSC attenuates HSCs failure in Shwachman-Diamond syndrome.
Kumar S, Nattamai KJ, Hassan A, Amoah A, Karns R, Zhang C, Liang Y, Shimamura A, Florian MC, Bissels U, Luevano M, Bosio A, Davies SM, Mulaw M, Geiger H, Myers KC.
Leukemia. 2020 Oct
Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice
Florian MC, Leins H, Gobs M, Han Y, Marka G, Soller K, Vollmer A, Sakk V, Nattamai KJ, Rayes A, Zhao X, Setchell K, Mulaw M, Wagner W, Zheng Y, Geiger H.
Aging Cell. 2020 Aug
TLR4-dependent shaping of the wound site by MSCs accelerates wound healing
Munir S, Basu A, Maity P, Krug L, Haas P, Jiang D, Strauss G, Wlaschek M, Geiger H, Singh K, Scharffetter-Kochanek K.
EMBO Rep. 2020 Mar
Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway
Kared H, Tan SW, Lau MC, Chevrier M, Tan C, How W, Wong G, Strickland M, Malleret B, Amoah A, Pilipow K, Zanon V, Govern NM, Lum J, Chen JM, Lee B, Florian MC, Geiger H, Ginhoux F, et al., Larbi A
Nat Commun. 2020 Feb
2019
HPRT and Purine Salvaging Are Critical for Hematopoietic Stem Cell Function
Vogel M, Moehrle B, Brown A, Eiwen K, Sakk V, Geiger H
Stem Cells. 2019 Dec
Haematopoietic stem cells in perisinusoidal niches are protected from ageing
Saçma M, Pospiech J, Bogeska R, de Back W, Mallm JP, Sakk V, Soller K, Marka G, Vollmer A, Karns R, Cabezas-Wallscheid N, Trumpp A, Méndez-Ferrer S, Milsom MD, Mulaw MA, Geiger H, Florian MC.
Nat Cell Biol. 2019 Nov
Lazy Sundays: role of day of the week and reactivity on objectively measured physical activity in older people
Klenk J, Peter RS, Rapp K, Dallmeier D, Rothenbacher D, Denkinger M, Büchele G; ActiFE Study Group, Becker T, Böhm B, Scharffetter-Kochanek K, Stingl J, Koenig W, Riepe M, Peter R, Geiger H, Ludolph A, von Arnim C, et al., Laszlo R
Eur Rev Aging Phys Act. 2019 Oct
Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML)
Agrawal M, Schwarz P, Giaimo BD, Bedzhov I, Corbacioglu A, Weber D, Gaidzik VI, Jahn N, Rücker FG, Schroeder T, Kindler T, Wattad M, Götze K, Lübbert M, et al., Bullinger L, Paschka P, Döhner K, Oswald F
Leukemia. 2019 Aug
Hematopoietic Stem Cell Dynamics Are Regulated by Progenitor Demand: Lessons from a Quantitative Modeling Approach
Klose M, Florian MC, Gerbaulet A, Geiger H, Glauche I
Stem Cells. 2019 Jul
Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance
Zhang C, Fondufe-Mittendorf YN, Wang C, Chen J, Cheng Q, Zhou D, Zheng Y, Geiger H, Liang Y
Haematologica. 2019 Jun
The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function
Brown A, Schuetz D, Han Y, Daria D, Nattamai KJ, Eiwen K, Sakk V, Pospiech J, Saller T, van Zant G, Wagner W, Geiger H
Haematologica. 2019 May
Distinct Dynamics of Stem and Progenitor Cells in Blood of Polytraumatized Patients
Vogel M, Christow H, Manz I, Denkinger M, Amoah A, Schütz D, Brown A, Möhrle B, Schaffer A, Kalbitz M, Gebhard F, Mayer B, Huber-Lang M, Geiger H
Shock. 2019 Apr
2018
Impaired immune surveillance accelerates accumulation of senescent cells and aging
Ovadya Y, Landsberger T, Leins H, Vadai E, Gal H, Biran A, Yosef R, Sagiv A, Agrawal A, Shapira A, Windheim J, Tsoory M, Schirmbeck R, Amit I, Geiger H, Krizhanovsky V.
Nat Commun. 2018 Dec
LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells
Grigoryan A, Guidi N, Senger K, Liehr T, Soller K, Marka G, Vollmer A, Markaki Y, Leonhardt H, Buske C, Lipka DB, Plass C, Zheng Y, Mulaw MA, Geiger H, Florian MC
Genome Biol. 2018 Nov
Chromosome integrity checkpoints in stem and progenitor cells: transitions upon differentiation, pathogenesis, and aging
Brown A, Geiger H
Cell Mol Life Sci. 2018 Oct
Aging alters the epigenetic asymmetry of HSC division
Florian MC, Klose M, Sacma M, Jablanovic J, Knudson L, Nattamai KJ, Marka G, Vollmer A, Soller K, Sakk V, Cabezas-Wallscheid N, Zheng Y, Mulaw MA, Glauche I, Geiger H
PLoS Biol. 2018 Sep
A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells
Du W, Liu W, Mizukawa B, Shang X, Sipple J, Wunderlich M, Geiger H, Davies S, Mulloy J, Pang Q, Zheng Y
Leukemia. 2018 Sep
Epigenetic age-predictor for mice based on three CpG sites
Han Y, Eipel M, Franzen J, Sakk V, Dethmers-Ausema B, Yndriago L, Izeta A, de Haan G, Geiger H, Wagner W
Elife. 2018 Aug
Aged murine hematopoietic stem cells drive aging-associated immune remodeling
Leins H, Mulaw M, Eiwen K, Sakk V, Liang Y, Denkinger M, Geiger H, Schirmbeck R
Blood. 2018 Aug
Special section: Replication stress, a threat to the nuclear and mitochondrial genome
Wiesmüller L, Scharffetter-Kochanek K, Geiger H
Mutat Res. 2018 Jan
Rho-inhibiting C2IN-C3 fusion toxin inhibits chemotactic recruitment of human monocytes ex vivo and in mice in vivo
Martin T, Möglich A, Felix I, Förtsch C, Rittlinger A, Palmer A, Denk S, Schneider J, Notbohm L, Vogel M, Geiger H, Paschke S, Huber-Lang M, Barth H.
Arch Toxicol. 2018 Jan
2017
Balance your folate or the yin and yang of folate in hematopoiesis
Geiger H
Haematologica. 2017 Dec
RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance
Liu M, Zhang Z, Sampson L, Zhou X, Nalapareddy K, Feng Y, Akunuru S, Melendez J, Davis AK, Bi F, Geiger H, Xin M, Zheng Y
Stem Cell Reports. 2017 Dec
Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors
Serrano-Lopez J, Nattamai K, Pease NA, Shephard MS, Wellendorf AM, Sertorio M, Smith EA, Geiger H, Wells SI, Cancelas JA, Privette Vinnedge LM.
Exp Hematol. 2017 Dec
The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment
Brown A, Pospiech J, Eiwen K, Baker DJ, Moehrle B, Sakk V, Nattamai K, Vogel M, Grigoryan A, Geiger H
Stem Cell Rep. 2017 Nov
Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation
Thiel VN, Giaimo BD, Schwarz P, Soller K, Vas V, Bartkuhn M, Blätte TJ, Döhner K, Bullinger L, Borggrefe T, Geiger H, Oswald F
Leukemia. 2017 Nov
HSC Niche Biology and HSC Expansion Ex Vivo
Kumar S, Geiger H
Trends Mol Med. 2017 Sep